2008 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 7 | vs | ARI | L | 13-23 | Candlestick Park |
| 2 | Sep 14 | @ | SEA | W | 33-30 OT | Qwest Field |
| 3 | Sep 21 | vs | DET | W | 31-13 | Candlestick Park |
| 4 | Sep 28 | @ | NO | L | 17-31 | Louisiana Superdome |
| 5 | Oct 5 | vs | NE | L | 21-30 | Candlestick Park |
| 6 | Oct 12 | vs | PHI | L | 26-40 | Candlestick Park |
| 7 | Oct 19 | @ | NYG | L | 17-29 | Giants Stadium |
| 8 | Oct 26 | vs | SEA | L | 13-34 | Candlestick Park |
| 10 | Nov 10 | @ | ARI | L | 24-29 | University of Phoenix Stadium |
| 11 | Nov 16 | vs | St. Louis Rams | W | 35-16 | Candlestick Park |
| 12 | Nov 23 | @ | DAL | L | 22-35 | Texas Stadium |
| 13 | Nov 30 | @ | BUF | W | 10-3 | Ralph Wilson Stadium |
| 14 | Dec 7 | vs | NYJ | W | 24-14 | Candlestick Park |
| 15 | Dec 14 | @ | MIA | L | 9-14 | Dolphin Stadium |
| 16 | Dec 21 | @ | St. Louis Rams | W | 17-16 | Edward Jones Dome |
| 17 | Dec 28 | vs | Washington Redskins | W | 27-24 | Candlestick Park |