2022 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 11 | @ | CHI | L | 10-19 | Soldier Field |
| 2 | Sep 18 | vs | SEA | W | 27-7 | Levi's Stadium |
| 3 | Sep 25 | @ | DEN | L | 10-11 | Empower Field at Mile High |
| 4 | Oct 3 | vs | Los Angeles Rams | W | 24-9 | Levi's Stadium |
| 5 | Oct 9 | @ | CAR | W | 37-15 | Bank of America Stadium |
| 6 | Oct 16 | @ | ATL | L | 14-28 | Mercedes-Benz Stadium |
| 7 | Oct 23 | vs | KC | L | 23-44 | Levi's Stadium |
| 8 | Oct 30 | @ | Los Angeles Rams | W | 31-14 | SoFi Stadium |
| 10 | Nov 13 | vs | Los Angeles Chargers | W | 22-16 | Levi's Stadium |
| 11 | Nov 21 | @ | ARI | W | 38-10 | Azteca Stadium |
| 12 | Nov 27 | vs | NO | W | 13-0 | Levi's Stadium |
| 13 | Dec 4 | vs | MIA | W | 33-17 | Levi's Stadium |
| 14 | Dec 11 | vs | TB | W | 35-7 | Levi's Stadium |
| 15 | Dec 15 | @ | SEA | W | 21-13 | Lumen Field |
| 16 | Dec 24 | vs | Washington Commanders | W | 37-20 | Levi's Stadium |
| 17 | Jan 1 | @ | Las Vegas Raiders | W | 37-34 OT | Allegiant Stadium |
| 18 | Jan 8 | vs | ARI | W | 38-13 | Levi's Stadium |