2021 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | @ | DET | W | 41-33 | Ford Field |
| 2 | Sep 19 | @ | PHI | W | 17-11 | Lincoln Financial Field |
| 3 | Sep 26 | vs | GB | L | 28-30 | Levi's Stadium |
| 4 | Oct 3 | vs | SEA | L | 21-28 | Levi's Stadium |
| 5 | Oct 10 | @ | ARI | L | 10-17 | State Farm Stadium |
| 7 | Oct 24 | vs | IND | L | 18-30 | Levi's Stadium |
| 8 | Oct 31 | @ | CHI | W | 33-22 | Soldier Field |
| 9 | Nov 7 | vs | ARI | L | 17-31 | Levi's Stadium |
| 10 | Nov 15 | vs | Los Angeles Rams | W | 31-10 | Levi's Stadium |
| 11 | Nov 21 | @ | JAX | W | 30-10 | TIAA Bank Stadium |
| 12 | Nov 28 | vs | MIN | W | 34-26 | Levi's Stadium |
| 13 | Dec 5 | @ | SEA | L | 23-30 | Lumen Field |
| 14 | Dec 12 | @ | CIN | W | 26-23 OT | Paul Brown Stadium |
| 15 | Dec 19 | vs | ATL | W | 31-13 | Levi's Stadium |
| 16 | Dec 23 | @ | Tennessee Titans | L | 17-20 | Nissan Stadium |
| 17 | Jan 2 | vs | HOU | W | 23-7 | Levi's Stadium |
| 18 | Jan 9 | @ | Los Angeles Rams | W | 27-24 OT | SoFi Stadium |