2016 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | vs | Los Angeles Rams | W | 28-0 | Levi's Stadium |
| 2 | Sep 18 | @ | CAR | L | 27-46 | Bank of America Stadium |
| 3 | Sep 25 | @ | SEA | L | 18-37 | CenturyLink Field |
| 4 | Oct 2 | vs | DAL | L | 17-24 | Levi's Stadium |
| 5 | Oct 6 | vs | ARI | L | 21-33 | Levi's Stadium |
| 6 | Oct 16 | @ | BUF | L | 16-45 | New Era Field |
| 7 | Oct 23 | vs | TB | L | 17-34 | Levi's Stadium |
| 9 | Nov 6 | vs | NO | L | 23-41 | Levi's Stadium |
| 10 | Nov 13 | @ | ARI | L | 20-23 | University of Phoenix Stadium |
| 11 | Nov 20 | vs | NE | L | 17-30 | Levi's Stadium |
| 12 | Nov 27 | @ | MIA | L | 24-31 | Hard Rock Stadium |
| 13 | Dec 4 | @ | CHI | L | 6-26 | Soldier Field |
| 14 | Dec 11 | vs | NYJ | L | 17-23 OT | Levi's Stadium |
| 15 | Dec 18 | @ | ATL | L | 13-41 | Georgia Dome |
| 16 | Dec 24 | @ | Los Angeles Rams | W | 22-21 | Los Angeles Memorial Coliseum |
| 17 | Jan 1 | vs | SEA | L | 23-25 | Levi's Stadium |