2010 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | vs | IND | W | 34-24 | Reliant Stadium |
| 2 | Sep 19 | @ | Washington Redskins | W | 30-27 OT | FedExField |
| 3 | Sep 26 | vs | DAL | L | 13-27 | Reliant Stadium |
| 4 | Oct 3 | @ | Oakland Raiders | W | 31-24 | Oakland-Alameda County Coliseum |
| 5 | Oct 10 | vs | NYG | L | 10-34 | Reliant Stadium |
| 6 | Oct 17 | vs | KC | W | 35-31 | Reliant Stadium |
| 8 | Nov 1 | @ | IND | L | 17-30 | Lucas Oil Stadium |
| 9 | Nov 7 | vs | San Diego Chargers | L | 23-29 | Reliant Stadium |
| 10 | Nov 14 | @ | JAX | L | 24-31 | EverBank Field |
| 11 | Nov 21 | @ | NYJ | L | 27-30 | New Meadowlands Stadium |
| 12 | Nov 28 | vs | Tennessee Titans | W | 20-0 | Reliant Stadium |
| 13 | Dec 2 | @ | PHI | L | 24-34 | Lincoln Financial Field |
| 14 | Dec 13 | vs | BAL | L | 28-34 OT | Reliant Stadium |
| 15 | Dec 19 | @ | Tennessee Titans | L | 17-31 | LP Field |
| 16 | Dec 26 | @ | DEN | L | 23-24 | Invesco Field at Mile High |
| 17 | Jan 2 | vs | JAX | W | 34-17 | Reliant Stadium |