2021 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 13 | vs | BAL | W | 33-27 OT | Allegiant Stadium |
| 2 | Sep 19 | @ | PIT | W | 26-17 | Heinz Field |
| 3 | Sep 26 | vs | MIA | W | 31-28 OT | Allegiant Stadium |
| 4 | Oct 4 | @ | Los Angeles Chargers | L | 14-28 | SoFi Stadium |
| 5 | Oct 10 | vs | CHI | L | 9-20 | Allegiant Stadium |
| 6 | Oct 17 | @ | DEN | W | 34-24 | Empower Field at Mile High |
| 7 | Oct 24 | vs | PHI | W | 33-22 | Allegiant Stadium |
| 9 | Nov 7 | @ | NYG | L | 16-23 | MetLife Stadium |
| 10 | Nov 14 | vs | KC | L | 14-41 | Allegiant Stadium |
| 11 | Nov 21 | vs | CIN | L | 13-32 | Allegiant Stadium |
| 12 | Nov 25 | @ | DAL | W | 36-33 | AT&T Stadium |
| 13 | Dec 5 | vs | Washington Football Team | L | 15-17 | Allegiant Stadium |
| 14 | Dec 12 | @ | KC | L | 9-48 | GEHA Field at Arrowhead Stadium |
| 15 | Dec 20 | @ | CLE | W | 16-14 | FirstEnergy Stadium |
| 16 | Dec 26 | vs | DEN | W | 17-13 | Allegiant Stadium |
| 17 | Jan 2 | @ | IND | W | 23-20 | Lucas Oil Stadium |
| 18 | Jan 9 | vs | Los Angeles Chargers | W | 35-32 OT | Allegiant Stadium |