2010 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | @ | HOU | L | 24-34 | Reliant Stadium |
| 2 | Sep 19 | vs | NYG | W | 38-14 | Lucas Oil Stadium |
| 3 | Sep 26 | @ | DEN | W | 27-13 | Invesco Field at Mile High |
| 4 | Oct 3 | @ | JAX | L | 28-31 | EverBank Field |
| 5 | Oct 10 | vs | KC | W | 19-9 | Lucas Oil Stadium |
| 6 | Oct 17 | @ | Washington Redskins | W | 27-24 | FedExField |
| 8 | Nov 1 | vs | HOU | W | 30-17 | Lucas Oil Stadium |
| 9 | Nov 7 | @ | PHI | L | 24-26 | Lincoln Financial Field |
| 10 | Nov 14 | vs | CIN | W | 23-17 | Lucas Oil Stadium |
| 11 | Nov 21 | @ | NE | L | 28-31 | Gillette Stadium |
| 12 | Nov 28 | vs | San Diego Chargers | L | 14-36 | Lucas Oil Stadium |
| 13 | Dec 5 | vs | DAL | L | 35-38 OT | Lucas Oil Stadium |
| 14 | Dec 9 | @ | Tennessee Titans | W | 30-28 | LP Field |
| 15 | Dec 19 | vs | JAX | W | 34-24 | Lucas Oil Stadium |
| 16 | Dec 26 | @ | Oakland Raiders | W | 31-26 | Oakland-Alameda County Coliseum |
| 17 | Jan 2 | vs | Tennessee Titans | W | 23-20 | Lucas Oil Stadium |