2021 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 13 | @ | Las Vegas Raiders | L | 27-33 OT | Allegiant Stadium |
| 2 | Sep 19 | vs | KC | W | 36-35 | M&T Bank Stadium |
| 3 | Sep 26 | @ | DET | W | 19-17 | Ford Field |
| 4 | Oct 3 | @ | DEN | W | 23-7 | Empower Field at Mile High |
| 5 | Oct 11 | vs | IND | W | 31-25 OT | M&T Bank Stadium |
| 6 | Oct 17 | vs | Los Angeles Chargers | W | 34-6 | M&T Bank Stadium |
| 7 | Oct 24 | vs | CIN | L | 17-41 | M&T Bank Stadium |
| 9 | Nov 7 | vs | MIN | W | 34-31 OT | M&T Bank Stadium |
| 10 | Nov 11 | @ | MIA | L | 10-22 | Hard Rock Stadium |
| 11 | Nov 21 | @ | CHI | W | 16-13 | Soldier Field |
| 12 | Nov 28 | vs | CLE | W | 16-10 | M&T Bank Stadium |
| 13 | Dec 5 | @ | PIT | L | 19-20 | Heinz Field |
| 14 | Dec 12 | @ | CLE | L | 22-24 | FirstEnergy Stadium |
| 15 | Dec 19 | vs | GB | L | 30-31 | M&T Bank Stadium |
| 16 | Dec 26 | @ | CIN | L | 21-41 | Paul Brown Stadium |
| 17 | Jan 2 | vs | Los Angeles Rams | L | 19-20 | M&T Bank Stadium |
| 18 | Jan 9 | vs | PIT | L | 13-16 OT | M&T Bank Stadium |