2010 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | vs | ARI | L | 13-17 | Edward Jones Dome |
| 2 | Sep 19 | @ | Oakland Raiders | L | 14-16 | Oakland-Alameda County Coliseum |
| 3 | Sep 26 | vs | Washington Redskins | W | 30-16 | Edward Jones Dome |
| 4 | Oct 3 | vs | SEA | W | 20-3 | Edward Jones Dome |
| 5 | Oct 10 | @ | DET | L | 6-44 | Ford Field |
| 6 | Oct 17 | vs | San Diego Chargers | W | 20-17 | Edward Jones Dome |
| 7 | Oct 24 | @ | TB | L | 17-18 | Raymond James Stadium |
| 8 | Oct 31 | vs | CAR | W | 20-10 | Edward Jones Dome |
| 10 | Nov 14 | @ | SF | L | 20-23 OT | Candlestick Park |
| 11 | Nov 21 | vs | ATL | L | 17-34 | Edward Jones Dome |
| 12 | Nov 28 | @ | DEN | W | 36-33 | Invesco Field at Mile High |
| 13 | Dec 5 | @ | ARI | W | 19-6 | University of Phoenix Stadium |
| 14 | Dec 12 | @ | NO | L | 13-31 | Louisiana Superdome |
| 15 | Dec 19 | vs | KC | L | 13-27 | Edward Jones Dome |
| 16 | Dec 26 | vs | SF | W | 25-17 | Edward Jones Dome |
| 17 | Jan 2 | @ | SEA | L | 6-16 | Qwest Field |