2010 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | @ | SEA | L | 6-31 | Qwest Field |
| 2 | Sep 20 | vs | NO | L | 22-25 | Candlestick Park |
| 3 | Sep 26 | @ | KC | L | 10-31 | Arrowhead Stadium |
| 4 | Oct 3 | @ | ATL | L | 14-16 | Georgia Dome |
| 5 | Oct 10 | vs | PHI | L | 24-27 | Candlestick Park |
| 6 | Oct 17 | vs | Oakland Raiders | W | 17-9 | Candlestick Park |
| 7 | Oct 24 | @ | CAR | L | 20-23 | Bank of America Stadium |
| 8 | Oct 31 | vs | DEN | W | 24-16 | Wembley Stadium |
| 10 | Nov 14 | vs | St. Louis Rams | W | 23-20 OT | Candlestick Park |
| 11 | Nov 21 | vs | TB | L | 0-21 | Candlestick Park |
| 12 | Nov 29 | @ | ARI | W | 27-6 | University of Phoenix Stadium |
| 13 | Dec 5 | @ | GB | L | 16-34 | Lambeau Field |
| 14 | Dec 12 | vs | SEA | W | 40-21 | Candlestick Park |
| 15 | Dec 16 | @ | San Diego Chargers | L | 7-34 | Qualcomm Stadium |
| 16 | Dec 26 | @ | St. Louis Rams | L | 17-25 | Edward Jones Dome |
| 17 | Jan 2 | vs | ARI | W | 38-7 | Candlestick Park |