2021 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | vs | SEA | L | 16-28 | Lucas Oil Stadium |
| 2 | Sep 19 | vs | Los Angeles Rams | L | 24-27 | Lucas Oil Stadium |
| 3 | Sep 26 | @ | Tennessee Titans | L | 16-25 | Nissan Stadium |
| 4 | Oct 3 | @ | MIA | W | 27-17 | Hard Rock Stadium |
| 5 | Oct 11 | @ | BAL | L | 25-31 OT | M&T Bank Stadium |
| 6 | Oct 17 | vs | HOU | W | 31-3 | Lucas Oil Stadium |
| 7 | Oct 24 | @ | SF | W | 30-18 | Levi's Stadium |
| 8 | Oct 31 | vs | Tennessee Titans | L | 31-34 OT | Lucas Oil Stadium |
| 9 | Nov 4 | vs | NYJ | W | 45-30 | Lucas Oil Stadium |
| 10 | Nov 14 | vs | JAX | W | 23-17 | Lucas Oil Stadium |
| 11 | Nov 21 | @ | BUF | W | 41-15 | New Era Field |
| 12 | Nov 28 | vs | TB | L | 31-38 | Lucas Oil Stadium |
| 13 | Dec 5 | @ | HOU | W | 31-0 | NRG Stadium |
| 15 | Dec 18 | vs | NE | W | 27-17 | Lucas Oil Stadium |
| 16 | Dec 25 | @ | ARI | W | 22-16 | State Farm Stadium |
| 17 | Jan 2 | vs | Las Vegas Raiders | L | 20-23 | Lucas Oil Stadium |
| 18 | Jan 9 | @ | JAX | L | 11-26 | TIAA Bank Stadium |