2021 Schedule & Results
Regular Season
| Wk | Date | Opponent | Result | Score | Stadium | |
|---|---|---|---|---|---|---|
| 1 | Sep 12 | vs | JAX | W | 37-21 | NRG Stadium |
| 2 | Sep 19 | @ | CLE | L | 21-31 | FirstEnergy Stadium |
| 3 | Sep 23 | vs | CAR | L | 9-24 | NRG Stadium |
| 4 | Oct 3 | @ | BUF | L | 0-40 | New Era Field |
| 5 | Oct 10 | vs | NE | L | 22-25 | NRG Stadium |
| 6 | Oct 17 | @ | IND | L | 3-31 | Lucas Oil Stadium |
| 7 | Oct 24 | @ | ARI | L | 5-31 | State Farm Stadium |
| 8 | Oct 31 | vs | Los Angeles Rams | L | 22-38 | NRG Stadium |
| 9 | Nov 7 | @ | MIA | L | 9-17 | Hard Rock Stadium |
| 11 | Nov 21 | @ | Tennessee Titans | W | 22-13 | Nissan Stadium |
| 12 | Nov 28 | vs | NYJ | L | 14-21 | NRG Stadium |
| 13 | Dec 5 | vs | IND | L | 0-31 | NRG Stadium |
| 14 | Dec 12 | vs | SEA | L | 13-33 | NRG Stadium |
| 15 | Dec 19 | @ | JAX | W | 30-16 | TIAA Bank Stadium |
| 16 | Dec 26 | vs | Los Angeles Chargers | W | 41-29 | NRG Stadium |
| 17 | Jan 2 | @ | SF | L | 7-23 | Levi's Stadium |
| 18 | Jan 9 | vs | Tennessee Titans | L | 25-28 | NRG Stadium |